Anti-Human CD288/TLR8/PRO286 Recombinant Antibody (SAA1960) (HV511013)

Name: Anti-Human CD288/TLR8/PRO286 Recombinant Antibody (SAA1960)
Brand: abinScience
SKU: HV511013
Price: 196 USD
Availability: InStock

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50ug
100ug
1mg

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HV511013

Species reactivity

Human

Applications

ELISA

Host species

Mouse

Isotype

IgG2a, kappa

Clone ID

SAA1960

Clonality

Monoclonal

Target

Toll-like receptor 8, CD288, TLR8

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q9NR97

RRID

Anti-Human CD288/TLR8/PRO286 Antibody (SAA1960) (abinScience Cat# HV511013, RRID:AB_3727724)
_x005F_x000D_

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Toll-like receptor 8 (CD288/TLR8) is a ~119 kDa protein. Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of RNA degradation products specific to microorganisms that are initially processed by RNASET2. Recognizes GU-rich single-stranded RNA (GU-rich RNA) derived from SARS-CoV-2, SARS-CoV-1 and HIV-1 viruses. Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction. In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce pro-inflammatory cytokines and interferons, respectively.

1. Ishii, N. et al. (2014) Journal of immunology (Baltimore, Md. : 1950) 193, 5118-28. PMID: 25297876

2. Heinz, LX. et al. (2020) Nature 581, 316-322. PMID: 32433612

3. Greulich, W. et al. (2019) Cell 179, 1264-1275.e13. PMID: 31778653

4. Campbell, GR. et al. (2021) iScience 24, 102295. PMID: 33718825

5. Tanji, H. et al. (2013) Science (New York, N.Y.) 339, 1426-9. PMID: 23520111

6. Tanji, H. et al. (2015) Nature structural & molecular biology 22, 109-15. PMID: 25599397

7. Tanji, H. et al. (2016) Proceedings of the National Academy of Sciences of the United States of America 113, 3012-7. PMID: 26929371

8. Qin, J. et al. (2006) The Journal of biological chemistry 281, 21013-21021. PMID: 16737960

9. Doyle, SL. et al. (2007) The Journal of biological chemistry 282, 36953-60. PMID: 17932028

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human CD288/TLR8/PRO286 Antibody (SAA1960)

References

Datasheet

Anti-Human CD288/TLR8/PRO286 Recombinant Antibody (SAA1960).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human CD288/TLR8/PRO286 Recombinant Antibody (SAA1960) (HV511013)

Overview

Images

References

Datasheet

SDS

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