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| カタログ番号 | HV511013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | SAA1960 | ||||
| ターゲット | Toll-like receptor 8, CD288, TLR8 | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | Q9NR97 | ||||
| RRID | Anti-Human CD288/TLR8/PRO286 Antibody (SAA1960) (abinScience Cat# HV511013, RRID:AB_3727724) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Toll-like receptor 8 (CD288/TLR8) is a ~119 kDa protein. Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of RNA degradation products specific to microorganisms that are initially processed by RNASET2. Recognizes GU-rich single-stranded RNA (GU-rich RNA) derived from SARS-CoV-2, SARS-CoV-1 and HIV-1 viruses. Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction. In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce pro-inflammatory cytokines and interferons, respectively. 1. Ishii, N. et al. (2014) Journal of immunology (Baltimore, Md. : 1950) 193, 5118-28. PMID: 25297876 2. Heinz, LX. et al. (2020) Nature 581, 316-322. PMID: 32433612 3. Greulich, W. et al. (2019) Cell 179, 1264-1275.e13. PMID: 31778653 4. Campbell, GR. et al. (2021) iScience 24, 102295. PMID: 33718825 5. Tanji, H. et al. (2013) Science (New York, N.Y.) 339, 1426-9. PMID: 23520111 6. Tanji, H. et al. (2015) Nature structural & molecular biology 22, 109-15. PMID: 25599397 7. Tanji, H. et al. (2016) Proceedings of the National Academy of Sciences of the United States of America 113, 3012-7. PMID: 26929371 8. Qin, J. et al. (2006) The Journal of biological chemistry 281, 21013-21021. PMID: 16737960 9. Doyle, SL. et al. (2007) The Journal of biological chemistry 282, 36953-60. PMID: 17932028 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human CD288/TLR8/PRO286 Antibody (SAA1960)
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