Anti-Human Leptin R Recombinant Antibody (SAA0096) (HW637107)

Name: Anti-Human Leptin R Recombinant Antibody (SAA0096)
Brand: abinScience
SKU: HW637107
Price: 191 USD
Availability: InStock

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Vista general

Número de catálogo	HW637107
Reactividad de especies	Human
Aplicaciones	FCM
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG4, Kappa
ID de clon	SAA0096
Objetivo	Leptin receptor, OB-R, LEP-R, LEPR, OB receptor, OBR, HuB219, DB, CD295
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>95% as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	P48357
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Fondo	Leptin receptor (CD295/LEPR) is a ~132 kDa protein. Receptor for hormone LEP/leptin (Probable). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity. Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. 1. Carpenter, B. et al. (2012) Structure (London, England : 1993) 20, 487-97. PMID: 22405007 2. Clément, K. et al. (1998) Nature 392, 398-401. PMID: 9537324 3. Zhao, Y. et al. (2003) Biochemical and biophysical research communications 300, 247-52. PMID: 12504075 4. Cassano, S. et al. (2014) Metabolism: clinical and experimental 63, 1272-9. PMID: 25060689 5. Bennett, BD. et al. (1996) Current biology : CB 6, 1170-80. PMID: 8805376
Nota	For research use only.

Imágenes

SDS-PAGE

SDS-PAGE for Anti-Human CD295/LEPR Antibody (SAA0096)

Referencias

Datasheet

Anti-Human Leptin R Recombinant Antibody (SAA0096).pdf

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Formula

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