Anti-Human CD295/LEPR Recombinant Antibody (SAA0096), FITC (HW637117)

Name: Anti-Human CD295/LEPR Recombinant Antibody (SAA0096), FITC
Brand: abinScience
SKU: HW637117
Price: 223 USD
Availability: InStock

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Catalog No.	HW637117
Species reactivity	Human
Applications	FCM
Host species	Human
Isotype	IgG4, Kappa
Clone ID	SAA0096
Conjugation	FITC
Clonality	Monoclonal
Target	Leptin receptor, OB-R, LEP-R, LEPR, OB receptor, OBR, HuB219, DB, CD295
Endotoxin level	Please contact with the lab for this information.
Associated products	Human IgG4 (S228P) Recombinant Isotype Control Antibody (13R4), FITC
Accession	P48357
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Background	Leptin receptor (CD295/LEPR) is a ~132 kDa protein. Receptor for hormone LEP/leptin (Probable). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity. Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. 1. Carpenter, B. et al. (2012) Structure (London, England : 1993) 20, 487-97. PMID: 22405007 2. Clément, K. et al. (1998) Nature 392, 398-401. PMID: 9537324 3. Zhao, Y. et al. (2003) Biochemical and biophysical research communications 300, 247-52. PMID: 12504075 4. Cassano, S. et al. (2014) Metabolism: clinical and experimental 63, 1272-9. PMID: 25060689 5. Bennett, BD. et al. (1996) Current biology : CB 6, 1170-80. PMID: 8805376
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Human CD295/LEPR Recombinant Antibody (SAA0096), FITC.pdf

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Anti-Human CD295/LEPR Recombinant Antibody (SAA0096), FITC (HW637117)

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