Anti-Human Leptin R Recombinant Antibody (SAA0096) (HW637107)

Name: Anti-Human Leptin R Recombinant Antibody (SAA0096)
Brand: abinScience
SKU: HW637107
Price: 191 USD
Availability: InStock

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Overview

Catalog No.	HW637107
Species reactivity	Human
Applications	FCM
Host species	Human
Isotype	IgG4, Kappa
Clone ID	SAA0096
Clonality	Monoclonal
Target	Leptin receptor, OB-R, LEP-R, LEPR, OB receptor, OBR, HuB219, DB, CD295
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P48357
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	Leptin receptor (CD295/LEPR) is a ~132 kDa protein. Receptor for hormone LEP/leptin (Probable). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity. Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. 1. Carpenter, B. et al. (2012) Structure (London, England : 1993) 20, 487-97. PMID: 22405007 2. Clément, K. et al. (1998) Nature 392, 398-401. PMID: 9537324 3. Zhao, Y. et al. (2003) Biochemical and biophysical research communications 300, 247-52. PMID: 12504075 4. Cassano, S. et al. (2014) Metabolism: clinical and experimental 63, 1272-9. PMID: 25060689 5. Bennett, BD. et al. (1996) Current biology : CB 6, 1170-80. PMID: 8805376
Note	For research use only.

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SDS-PAGE for Anti-Human CD295/LEPR Antibody (SAA0096)

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Datasheet

Anti-Human Leptin R Recombinant Antibody (SAA0096).pdf

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Anti-Human Leptin R Recombinant Antibody (SAA0096) (HW637107)

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