Anti-Human CD316/IGSF8 Recombinant Antibody (SAA1612) (HV379013)

Name: Anti-Human CD316/IGSF8 Recombinant Antibody (SAA1612)
Brand: abinScience
SKU: HV379013
Price: 196 USD
Availability: InStock

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Precio(USD):

Especificación:

50ug
100ug
1mg

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HV379013

Reactividad de especies

Human

Aplicaciones

ELISA

Especie huésped

Mouse

Clonalidad

Monoclonal

Isotipo

IgG2a, kappa

ID de clon

SAA1612

Objetivo

EWI2, IGSF8, CD316, Glu-Trp-Ile EWI motif-containing protein 2, Keratinocytes-associated transmembrane protein 4, LIR-D1, Prostaglandin regulatory-like protein, CD81P3, EWI-2, KCT-4, CD81 partner 3, Immunoglobulin superfamily member 8, IgSF8, KCT4, PGRL

Nivel de endotoxinas

Please contact with the lab for this information.

Pureza

>95% as determined by SDS-PAGE.

Purificación

Protein A/G purified from cell culture supernatant.

Número de acceso

Q969P0

RRID

Anti-Human CD316/IGSF8 Antibody (SAA1612) (abinScience Cat# HV379013, RRID:AB_3727373)

Forma

Liquid

Buffer de almacenamiento

0.01M PBS pH 7.4

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:2000-1:20000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Fondo

Immunoglobulin superfamily member 8 (CD316/IGSF8) is a ~65 kDa protein. Member of the immunoglobulin superfamily (IgSF) that links tetraspanin-enriched microdomains to the actin cytoskeleton and plays several important roles in innate and adaptive immunity. Acts as an inducible receptor of HSPA8 on dendritic cells to enhance the CCL21/SLC-dependent migration of activated mature dendritic cells while attenuating their antigen-specific stimulatory capacities. In complex with alpha-actinins ACTN1 and ACTN4, regulates actin dynamics in the immune synapse and subsequent T-cell activation. Inhibits the entry of several viruses such as hepatitis C Virus (HCV) or HIV-1. Mechanistically, promotes a change in CD81 organization at the plasma membrane by significantly restricting its diffusion which in turn influences CD81 interaction with Claudin-1/CLDN1, preventing CLDN1 from acting as a co-receptor required for HCV entry.

1. Stipp, CS. et al. (2001) The Journal of biological chemistry 276, 40545-54. PMID: 11504738

2. Stipp, CS. et al. (2003) The Journal of cell biology 163, 1167-77. PMID: 14662754

3. Kettner, S. et al. (2007) Molecular and cellular biology 27, 7718-26. PMID: 17785435

4. Gordón-Alonso, M. et al. (2012) Journal of immunology (Baltimore, Md. : 1950) 189, 689-700. PMID: 22689882

5. Potel, J. et al. (2013) Cellular microbiology 15, 1234-52. PMID: 23351194

6. Whitaker, EE. et al. (2019) Viruses 11. PMID: 31757023

7. Li, Y. et al. (2024) Cell 187, 2703-2716.e23. PMID: 38657602

Nota

For research use only.

Imágenes

SDS-PAGE

SDS-PAGE for Anti-Human CD316/IGSF8 Antibody (SAA1612)

Referencias

Datasheet

Anti-Human CD316/IGSF8 Recombinant Antibody (SAA1612).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo