Anti-Human CD316/IGSF8 Recombinant Antibody (SAA1612) (HV379013)

Name: Anti-Human CD316/IGSF8 Recombinant Antibody (SAA1612)
Brand: abinScience
SKU: HV379013
Price: 196 USD
Availability: InStock

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Spécification :

50ug
100ug
1mg

Nombre :

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Aperçu
Images
Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HV379013

Reactivité des espèces

Human

Applications

ELISA

Espèce hôte

Mouse

Clonalité

Monoclonal

Isotype

IgG2a, kappa

ID de clone

SAA1612

Cible

EWI2, IGSF8, CD316, Glu-Trp-Ile EWI motif-containing protein 2, Keratinocytes-associated transmembrane protein 4, LIR-D1, Prostaglandin regulatory-like protein, CD81P3, EWI-2, KCT-4, CD81 partner 3, Immunoglobulin superfamily member 8, IgSF8, KCT4, PGRL

Niveau d'endotoxines

Please contact with the lab for this information.

Pureté

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Numéro d'accès

Q969P0

RRID

Anti-Human CD316/IGSF8 Antibody (SAA1612) (abinScience Cat# HV379013, RRID:AB_3727373)

Forme

Liquid

Tampon de stockage

0.01M PBS pH 7.4

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:2000-1:20000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Contexte

Immunoglobulin superfamily member 8 (CD316/IGSF8) is a ~65 kDa protein. Member of the immunoglobulin superfamily (IgSF) that links tetraspanin-enriched microdomains to the actin cytoskeleton and plays several important roles in innate and adaptive immunity. Acts as an inducible receptor of HSPA8 on dendritic cells to enhance the CCL21/SLC-dependent migration of activated mature dendritic cells while attenuating their antigen-specific stimulatory capacities. In complex with alpha-actinins ACTN1 and ACTN4, regulates actin dynamics in the immune synapse and subsequent T-cell activation. Inhibits the entry of several viruses such as hepatitis C Virus (HCV) or HIV-1. Mechanistically, promotes a change in CD81 organization at the plasma membrane by significantly restricting its diffusion which in turn influences CD81 interaction with Claudin-1/CLDN1, preventing CLDN1 from acting as a co-receptor required for HCV entry.

1. Stipp, CS. et al. (2001) The Journal of biological chemistry 276, 40545-54. PMID: 11504738

2. Stipp, CS. et al. (2003) The Journal of cell biology 163, 1167-77. PMID: 14662754

3. Kettner, S. et al. (2007) Molecular and cellular biology 27, 7718-26. PMID: 17785435

4. Gordón-Alonso, M. et al. (2012) Journal of immunology (Baltimore, Md. : 1950) 189, 689-700. PMID: 22689882

5. Potel, J. et al. (2013) Cellular microbiology 15, 1234-52. PMID: 23351194

6. Whitaker, EE. et al. (2019) Viruses 11. PMID: 31757023

7. Li, Y. et al. (2024) Cell 187, 2703-2716.e23. PMID: 38657602

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human CD316/IGSF8 Antibody (SAA1612)

Reférences

Fiche technique

Anti-Human CD316/IGSF8 Recombinant Antibody (SAA1612).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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