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| カタログ番号 | HV592013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | SAA1942 | ||||
| ターゲット | PAM-1, JAM1, Platelet F11 receptor, JCAM, JAM-A, F11R, Junctional adhesion molecule A, Junctional adhesion molecule 1, CD321, Platelet adhesion molecule 1, JAM-1 | ||||
| エンドトキシンレベル | < 10 EU/mg | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | Q9Y624 | ||||
| RRID | Anti-Human CD321/F11R/JAM-A Antibody (SAA1942) (abinScience Cat# HV592013, RRID:AB_3727706) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Junctional adhesion molecule A (CD321/F11R) is a ~32 kDa protein. Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration. 1. Itoh, M. et al. (2001) The Journal of cell biology 154, 491-7. PMID: 11489913 2. Ostermann, G. et al. (2002) Nature immunology 3, 151-8. PMID: 11812992 3. Sobocka, MB. et al. (2000) Blood 95, 2600-9. PMID: 10753840 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human CD321/F11R/JAM-A Antibody (SAA1942)
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