Anti-Human CD338/ABCG2 Recombinant Antibody (5D3), APC (HV314137)

Name: Anti-Human CD338/ABCG2 Recombinant Antibody (5D3), APC
Brand: abinScience
SKU: HV314137
Price: 290 USD
Availability: InStock

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Numéro de catalogue	HV314137
Reactivité des espèces	Human
Applications	FCM
Espèce hôte	Mouse
Clonalité	Monoclonal
Isotype	IgG1, kappa
ID de clone	5D3
Conjugaison	APC
Cible	Urate exporter, ABCP, BCRP1, ABCG2, CD338, BCRP, MXR, Broad substrate specificity ATP-binding cassette transporter ABCG2, Placenta-specific ATP-binding cassette transporter, Breast cancer resistance protein, Mitoxantrone resistance-associated protein, CDw338, ATP-binding cassette sub-family G member 2
Niveau d'endotoxines	Please contact with the lab for this information.
Produits associés	Mouse IgG1, kappa Recombinant Isotype Control Antibody (MOPC-21), APC
Numéro d'accès	Q9UNQ0
Forme	Liquid
Tampon de stockage	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Contexte	Broad substrate specificity ATP-binding cassette transporter ABCG2 (CD338) is a ~72 kDa protein. Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells. Involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from both mitochondria to cytosol and cytosol to extracellular space, it also functions in the cellular export of heme. Also mediates the efflux of sphingosine-1-P from cells. Acts as a urate exporter functioning in both renal and extrarenal urate excretion. In kidney, it also functions as a physiological exporter of the uremic toxin indoxyl sulfate. 1. Komatani, H. et al. (2001) Cancer research 61, 2827-32. PMID: 11306452 2. Zhang, W. et al. (2003) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 17, 2085-7. PMID: 12958161 3. Woodward, OM. et al. (2009) Proceedings of the National Academy of Sciences of the United States of America 106, 10338-42. PMID: 19506252 4. Desuzinges-Mandon, E. et al. (2010) The Journal of biological chemistry 285, 33123-33133. PMID: 20705604 5. Taylor, NMI. et al. (2017) Nature 546, 504-509. PMID: 28554189 6. Manolaridis, I. et al. (2018) Nature 563, 426-430. PMID: 30405239 7. Toyoda, Y. et al. (2019) Cells 8. PMID: 31003562 8. Kobuchi, H. et al. (2012) PloS one 7, e50082. PMID: 23189181 9. Takabe, K. et al. (2010) The Journal of biological chemistry 285, 10477-86. PMID: 20110355
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Human CD338/ABCG2 Recombinant Antibody (5D3), APC.pdf

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