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| カタログ番号 | HV585137 |
|---|---|
| 種反応性 | Human |
| アプリケーション | FCM |
| 宿主種 | Mouse |
| クローン性 | Monoclonal |
| アイソタイプ | IgG1, kappa |
| クローンID | NT-7 |
| 抱合 | APC |
| ターゲット | CD352, NTB-A, NK-T-B-antigen, KALI, SLAMF6, Activating NK receptor, SLAM family member 6 |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 関連製品 | Mouse IgG1, kappa Recombinant Isotype Control Antibody (MOPC-21), APC |
| アクセッション番号 | Q96DU3 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Store at 4°C for 12 months. Protect from light. Do not freeze. |
| 背景 | SLAM family member 6 (CD352/SLAMF6) is a ~37 kDa protein. Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. Positive signaling in NK cells implicates phosphorylation of VAV1. 1. Bottino, C. et al. (2001) The Journal of experimental medicine 194, 235-46. PMID: 11489943 2. Eissmann, P. et al. (2006) Journal of immunology (Baltimore, Md. : 1950) 177, 3170-7. PMID: 16920955 3. Chatterjee, M. et al. (2012) Journal of immunology (Baltimore, Md. : 1950) 188, 1206-12. PMID: 22184727 4. Chatterjee, M. et al. (2012) The Journal of biological chemistry 287, 38168-77. PMID: 22989874 |
| 注意事項 | For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only. |
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