

| Каталожный номер | HF685137 |
|---|---|
| Реактивность видов | Human |
| Применения | FCM |
| Хозяинский вид | Mouse |
| Клоональность | Monoclonal |
| Изотип | IgG1, kappa |
| ID клона | M53-E04 |
| Конъюгация | APC |
| Цель | DR6, Death receptor 6, Tumor necrosis factor receptor superfamily member 21, TNFRSF21, CD358 |
| Уровень эндотоксинов | Please contact with the lab for this information. |
| Связанные продукты | Mouse IgG1, kappa Recombinant Isotype Control Antibody (MOPC-21), APC |
| Номер доступа | O75509 |
| Форма | Liquid |
| Буфер хранения | 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
| Устойчивость и хранение | Store at 4°C for 12 months. Protect from light. Do not freeze. |
| Фон | Tumor necrosis factor receptor superfamily member 21 (CD358/TNFRSF21) is a ~71 kDa protein. Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. 1. Zhang, JY. et al. (2021) Cell research 31, 980-997. PMID: 34012073 |
| Примечание | For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only. |




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