Anti-Human CD358/TNFRSF21 Recombinant Antibody (M53-E04) (HF685107)

Name: Anti-Human CD358/TNFRSF21 Recombinant Antibody (M53-E04)
Brand: abinScience
SKU: HF685107
Price: 191 USD
Availability: InStock

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Overview

Catalog No.	HF685107
Species reactivity	Human
Applications	FCM
Host species	Mouse
Isotype	IgG1, kappa
Clone ID	M53-E04
Clonality	Monoclonal
Target	DR6, Death receptor 6, Tumor necrosis factor receptor superfamily member 21, TNFRSF21, CD358
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	O75509
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	Tumor necrosis factor receptor superfamily member 21 (CD358/TNFRSF21) is a ~71 kDa protein. Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. 1. Zhang, JY. et al. (2021) Cell research 31, 980-997. PMID: 34012073
Note	For research use only.

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Bioactivity

Detects CD358/TNFRSF21 in indirect ELISAs.

References

Datasheet

Anti-Human CD358/TNFRSF21 Recombinant Antibody (M53-E04).pdf

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Recombinant Proteins

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Anti-Human CD358/TNFRSF21 Recombinant Antibody (M53-E04) (HF685107)

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