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| カタログ番号 | HV829107 |
|---|---|
| 種反応性 | Human |
| アプリケーション | FCM |
| 宿主種 | Mouse |
| クローン性 | Monoclonal |
| アイソタイプ | IgG1, kappa |
| クローンID | 15E2# |
| ターゲット | Beta-glucan receptor, CD369, CLEC7A, DECTIN1, BGR, C-type lectin superfamily member 12, DC-associated C-type lectin 1, CLECSF12, Dectin-1, C-type lectin domain family 7 member A, Dendritic cell-associated C-type lectin 1 |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >95% as determined by SDS-PAGE. |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | Q9BXN2 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| 背景 | C-type lectin domain family 7 member A (CD369/CLEC7A) is a ~27 kDa protein. Lectin that functions as a pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B: upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10-MALT1 (CBM) signalosomes, leading to the activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. 1. Willment, JA. et al. (2001) The Journal of biological chemistry 276, 43818-23. PMID: 11567029 2. Grünebach, F. et al. (2002) Experimental hematology 30, 1309-15. PMID: 12423684 3. Kennedy, AD. et al. (2007) European journal of immunology 37, 467-78. PMID: 17230442 |
| 注意事項 | For research use only. |
Detects CD369/CLEC7A in indirect ELISAs.
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