Anti-Human CD369/CLEC7A Recombinant Antibody (15E2#), APC (HV829137)

Name: Anti-Human CD369/CLEC7A Recombinant Antibody (15E2#), APC
Brand: abinScience
SKU: HV829137
Price: 290 USD
Availability: InStock

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Overview

Catalog No.	HV829137
Species reactivity	Human
Applications	FCM
Host species	Mouse
Isotype	IgG1, kappa
Clone ID	15E2#
Conjugation	APC
Clonality	Monoclonal
Target	Beta-glucan receptor, CD369, CLEC7A, DECTIN1, BGR, C-type lectin superfamily member 12, DC-associated C-type lectin 1, CLECSF12, Dectin-1, C-type lectin domain family 7 member A, Dendritic cell-associated C-type lectin 1
Endotoxin level	Please contact with the lab for this information.
Associated products	Mouse IgG1, kappa Recombinant Isotype Control Antibody (MOPC-21), APC
Accession	Q9BXN2
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Background	C-type lectin domain family 7 member A (CD369/CLEC7A) is a ~27 kDa protein. Lectin that functions as a pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B: upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10-MALT1 (CBM) signalosomes, leading to the activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. 1. Willment, JA. et al. (2001) The Journal of biological chemistry 276, 43818-23. PMID: 11567029 2. Grünebach, F. et al. (2002) Experimental hematology 30, 1309-15. PMID: 12423684 3. Kennedy, AD. et al. (2007) European journal of immunology 37, 467-78. PMID: 17230442
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Datasheet

Anti-Human CD369/CLEC7A Recombinant Antibody (15E2#), APC.pdf

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Anti-Human CD369/CLEC7A Recombinant Antibody (15E2#), APC (HV829137)

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