Anti-Human CD48/SLAMF2 Recombinant Antibody (SAA0017), APC (HY573137)

Name: Anti-Human CD48/SLAMF2 Recombinant Antibody (SAA0017), APC
Brand: abinScience
SKU: HY573137
Price: 256 USD
Availability: InStock

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Каталожный номер	HY573137
Реактивность видов	Human
Применения	ELISA, FCM, WB
Хозяинский вид	Human
Клоональность	Monoclonal
Изотип	IgG1
ID клона	SAA0017
Конъюгация	APC
Цель	Signaling lymphocytic activation molecule 2, TCT.1, CD48 antigen, B-lymphocyte activation marker BLAST-1, BCM1, CD48, BLAST1, Leukocyte antigen MEM-102, SLAMF2, BCM1 surface antigen, SLAM family member 2, RHC39801
Уровень эндотоксинов	Please contact with the lab for this information.
Связанные продукты	Human IgG1 Recombinant Isotype Control Antibody (HyHEL-10), APC
Номер доступа	P09326
Форма	Liquid
Буфер хранения	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Store at 4°C for 12 months. Protect from light. Do not freeze.
Фон	CD48 antigen is a ~27 kDa protein. Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including CD244/2B4 or CD2 to regulate immune cell function and activation. Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex. In turn, promotes LCK phosphorylation and subsequent activation. Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK-cells. 1. Hawash, IY. et al. (2002) Biochimica et biophysica acta 1589, 140-50. PMID: 12007789 2. Muhammad, A. et al. (2009) Journal of immunology (Baltimore, Md. : 1950) 182, 7672-80. PMID: 19494291 3. Claus, M. et al. (2016) Open biology 6. PMID: 27249817 4. Brown, MH. et al. (1998) The Journal of experimental medicine 188, 2083-90. PMID: 9841922
Примечание	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.