Anti-Human CD48 Recombinant Antibody (SAA0017), FITC (HY573117)

Name: Anti-Human CD48 Recombinant Antibody (SAA0017), FITC
Brand: abinScience
SKU: HY573117
Price: 196 USD
Availability: InStock

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Overview

Catalog No.	HY573117
Species reactivity	Human
Applications	ELISA, FCM, WB
Host species	Human
Isotype	IgG1
Clone ID	SAA0017
Conjugation	FITC
Clonality	Monoclonal
Target	Signaling lymphocytic activation molecule 2, TCT.1, CD48 antigen, B-lymphocyte activation marker BLAST-1, BCM1, CD48, BLAST1, Leukocyte antigen MEM-102, SLAMF2, BCM1 surface antigen, SLAM family member 2, RHC39801
Endotoxin level	Please contact with the lab for this information.
Associated products	Human IgG1 Recombinant Isotype Control Antibody (HyHEL-10), FITC
Accession	P09326
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Background	CD48 antigen is a ~27 kDa protein. Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including CD244/2B4 or CD2 to regulate immune cell function and activation. Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex. In turn, promotes LCK phosphorylation and subsequent activation. Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK-cells. 1. Hawash, IY. et al. (2002) Biochimica et biophysica acta 1589, 140-50. PMID: 12007789 2. Muhammad, A. et al. (2009) Journal of immunology (Baltimore, Md. : 1950) 182, 7672-80. PMID: 19494291 3. Claus, M. et al. (2016) Open biology 6. PMID: 27249817 4. Brown, MH. et al. (1998) The Journal of experimental medicine 188, 2083-90. PMID: 9841922
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.