Anti-Human CD49e/ITGA5 Recombinant Antibody (SAA0021), APC (HY464137)

Name: Anti-Human CD49e/ITGA5 Recombinant Antibody (SAA0021), APC
Brand: abinScience
SKU: HY464137
Price: 256 USD
Availability: InStock

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概要
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概要

カタログ番号	HY464137
種反応性	Human
アプリケーション	FCM
宿主種	Human
クローン性	Monoclonal
アイソタイプ	IgG4
クローンID	SAA0021
抱合	APC
ターゲット	CD49 antigen-like family member E, Integrin alpha-F, ITGA5, VLA-5, Fibronectin receptor subunit alpha, CD49e, Integrin alpha-5, FNRA
エンドトキシンレベル	Please contact with the lab for this information.
関連製品	Human IgG4 (S228P) Recombinant Isotype Control Antibody (13R4), APC
アクセッション番号	P08648
形態	Liquid
保存バッファー	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Store at 4°C for 12 months. Protect from light. Do not freeze.
背景	Integrin alpha-5 (CD49e/ITGA5) is a ~114 kDa protein. Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. ITGA5:ITGB1 acts as a receptor for fibronectin (FN1) and mediates R-G-D-dependent cell adhesion to FN1. 1. Saegusa, J. et al. (2008) The Journal of biological chemistry 283, 26107-15. PMID: 18635536 2. Fujita, M. et al. (2015) The Journal of biological chemistry 290, 259-71. PMID: 25398877 3. Bax, DV. et al. (2003) The Journal of biological chemistry 278, 34605-16. PMID: 12807887 4. Jovanovic, J. et al. (2007) The Journal of biological chemistry 282, 6743-51. PMID: 17158881 5. Schumacher, S. et al. (2021) Science advances 7. PMID: 33962943 6. Takada, YK. et al. (2017) The Journal of biological chemistry 292, 20067-20075. PMID: 29030430 7. Takada, YK. et al. (2019) Journal of immunology (Baltimore, Md. : 1950) 203, 1383-1391. PMID: 31331973
注意事項	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Flow CytoMetry

Flow-cytometry using APC anti-human CD49e antibody. HUVEC cells were stained with an irrelevant antibody (Blue Histogram) or an APC anti-human CD49e monoclonal antibody (Catalog: HY464137, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.

参考文献

データシート