Anti-Human ICAM-1/CD54 Recombinant Antibody (SAA0025), APC (HY321137)

Name: Anti-Human ICAM-1/CD54 Recombinant Antibody (SAA0025), APC
Brand: abinScience
SKU: HY321137
Price: 256 USD
Availability: InStock

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Aperçu

Numéro de catalogue	HY321137
Reactivité des espèces	Human
Applications	ELISA, FCM
Espèce hôte	Human
Clonalité	Monoclonal
Isotype	IgG1, lambda
ID de clone	SAA0025
Conjugaison	APC
Applications testées	FCM
Cible	ICAM1, Major group rhinovirus receptor, CD54, ICAM-1, Intercellular adhesion molecule 1
Niveau d'endotoxines	Please contact with the lab for this information.
Produits associés	Human IgG1, lambda Isotype Control antibody (HyHEL-10), APC
Numéro d'accès	P05362
Forme	Liquid
Tampon de stockage	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Contexte	Intercellular adhesion molecule 1 (CD54/ICAM1) is a ~57 kDa protein. Cell adhesion molecule that functions as a receptor ligand of the signaling receptor ITGAL:ITGB2/LFA-1 (lymphocyte-function associated (LFA) molecule 1) ensuring leukocyte cell-cell adhesion, by providing a calibrated system to namely adjust T-cell killing to the antigen stimulation strength. Also functions as a ligand receptor of the signaling receptor ITGAM:ITGB2/MAC-1 ensuring adhesion between stimulated neutrophils and stimulated endothelial cells. During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. Promotes cell aggregation in epithelial cells through interaction with MUC1. 1. Dustin, ML. et al. (1986) Journal of immunology (Baltimore, Md. : 1950) 137, 245-54. PMID: 3086451 2. Simmons, D. et al. (1988) Nature 331, 624-7. PMID: 3340213 3. Lacouture, C. et al. (2024) Nature communications 15, 407. PMID: 38195629 4. Diamond, MS. et al. (1990) The Journal of cell biology 111, 3129-39. PMID: 1980124 5. van Buul, JD. et al. (2007) The Journal of cell biology 178, 1279-93. PMID: 17875742 6. Hayashi, T. et al. (2001) Digestion 63 Suppl 1, 87-92. PMID: 11173916
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Flow CytoMetry

Flow-cytometry using APC anti-human CD54 antibody. RPMI-8226 cells were stained with an irrelevant antibody (Blue Histogram) or an APC anti-human CD54 monoclonal antibody (Catalog: HY321137, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.

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