Anti-Human ICAM-1/CD54 Reference Antibody (Mor102, RUO) (HY321046)

Name: Anti-Human ICAM-1/CD54 Reference Antibody (Mor102, RUO)
Brand: abinScience
SKU: HY321046
Price: 176 USD
Availability: InStock

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Overview

Catalog No.	HY321046
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	Fab-G4-nd
Biological activity	MOR102 (0.04-10 ug/mL; 30 min) potently inhibits adhesion of human SKW-3 T-cell leukaemia cells to immobilized recombinant ICAM-1 with an IC 50 of 3 nM [1]. MOR102 (0.5-50 ug/mL; 4 days) reduces proliferation of human peripheral blood mononuclear cells in mixed lymphocyte cultures [1]. MOR102 (10 ug/mL; overnight) binds to human HaCaT keratinocytes, with increased binding observed on IFN-γ-stimulated HaCaT cells [1]. MOR102 (10 mg/kg; i.p.; every alternate day; 4 weeks from day 22-50 after transplantation) significantly reduces epidermal thickness and inflammatory infiltrate in a psoriasis- SCID mouse model [1]. MOR102 (10 mg/kg; i.p.; every other day; 4 weeks) induces orthokeratotic differentiation, reduces epidermal thickness, and decreases inflammatory infiltrate in human chronic plaque-stage psoriasis skin grafts on SCID mice [2].
Expression system	Mammalian cells
Clonality	Monoclonal
Target	ICAM1, Major group rhinovirus receptor, CD54, ICAM-1, Intercellular adhesion molecule 1
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P05362
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	MOR102
Background	Intercellular adhesion molecule 1 (CD54/ICAM1) is a ~57 kDa protein. Cell adhesion molecule that functions as a receptor ligand of the signaling receptor ITGAL:ITGB2/LFA-1 (lymphocyte-function associated (LFA) molecule 1) ensuring leukocyte cell-cell adhesion, by providing a calibrated system to namely adjust T-cell killing to the antigen stimulation strength. Also functions as a ligand receptor of the signaling receptor ITGAM:ITGB2/MAC-1 ensuring adhesion between stimulated neutrophils and stimulated endothelial cells. During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. Promotes cell aggregation in epithelial cells through interaction with MUC1. 1. Dustin, ML. et al. (1986) Journal of immunology (Baltimore, Md. : 1950) 137, 245-54. PMID: 3086451 2. Simmons, D. et al. (1988) Nature 331, 624-7. PMID: 3340213 3. Lacouture, C. et al. (2024) Nature communications 15, 407. PMID: 38195629 4. Diamond, MS. et al. (1990) The Journal of cell biology 111, 3129-39. PMID: 1980124 5. van Buul, JD. et al. (2007) The Journal of cell biology 178, 1279-93. PMID: 17875742 6. Hayashi, T. et al. (2001) Digestion 63 Suppl 1, 87-92. PMID: 11173916
References	1. Boehncke WH, et al. Efficacy of the fully human monoclonal antibody MOR102 (#5) against intercellular adhesion molecule 1 in the psoriasis-severe combined immunodeficient mouse model. Br J Dermatol. 2005;153(4):758-766. [HY321046] 2. Mrowietz U, et al. Leukocyte adhesion: a suitable target for anti-inflammatory drugs. Curr Pharm Des. 2006;12(22):2825-2831. [HY321046]
Note	For research use only. Not suitable for clinical or therapeutic use.