Anti-Human ICAM-1/CD54 Polyclonal Antibody (HY321014)

Name: Anti-Human ICAM-1/CD54 Polyclonal Antibody
Brand: abinScience
SKU: HY321014
Price: 168 USD
Availability: InStock

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Precio(USD):

Especificación:

50ug
100ug

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HY321014

Reactividad de especies

Human

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human CD54/ICAM1 (Gln28-Glu480).

Objetivo

ICAM1, Major group rhinovirus receptor, CD54, ICAM-1, Intercellular adhesion molecule 1

Purificación

Purified by antigen affinity column.

Número de acceso

P05362

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Intercellular adhesion molecule 1 (CD54/ICAM1) is a ~57 kDa protein. Cell adhesion molecule that functions as a receptor ligand of the signaling receptor ITGAL:ITGB2/LFA-1 (lymphocyte-function associated (LFA) molecule 1) ensuring leukocyte cell-cell adhesion, by providing a calibrated system to namely adjust T-cell killing to the antigen stimulation strength. Also functions as a ligand receptor of the signaling receptor ITGAM:ITGB2/MAC-1 ensuring adhesion between stimulated neutrophils and stimulated endothelial cells. During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. Promotes cell aggregation in epithelial cells through interaction with MUC1.

1. Dustin, ML. et al. (1986) Journal of immunology (Baltimore, Md. : 1950) 137, 245-54. PMID: 3086451

2. Simmons, D. et al. (1988) Nature 331, 624-7. PMID: 3340213

3. Lacouture, C. et al. (2024) Nature communications 15, 407. PMID: 38195629

4. Diamond, MS. et al. (1990) The Journal of cell biology 111, 3129-39. PMID: 1980124

5. van Buul, JD. et al. (2007) The Journal of cell biology 178, 1279-93. PMID: 17875742

6. Hayashi, T. et al. (2001) Digestion 63 Suppl 1, 87-92. PMID: 11173916

Nota

For research use only.

Imágenes

Referencias

Datasheet