Anti-Human CD5L Recombinant Antibody (SAA1515) (HT064013)

Name: Anti-Human CD5L Recombinant Antibody (SAA1515)
Brand: abinScience
SKU: HT064013
Price: 196 USD
Availability: InStock

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Precio(USD):

Especificación:

50ug
100ug
1mg

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HT064013

Reactividad de especies

Human

Aplicaciones

ELISA

Especie huésped

Mouse

Clonalidad

Monoclonal

Isotipo

IgG2a, kappa

ID de clon

SAA1515

Objetivo

CD5 antigen-like, Apoptosis inhibitor expressed by macrophages, IgM-associated peptide, CT-2, hAIM, API6, SP-alpha, CD5L

Nivel de endotoxinas

Please contact with the lab for this information.

Pureza

>95% as determined by SDS-PAGE.

Purificación

Protein A/G purified from cell culture supernatant.

Número de acceso

O43866

RRID

Anti-Human CD5L Antibody (SAA1515) (abinScience Cat# HT064013, RRID:AB_3727276)

Forma

Liquid

Buffer de almacenamiento

0.01M PBS pH 7.4

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:2000-1:20000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Fondo

CD5 antigen-like (CD5L) is a ~38 kDa protein. Secreted protein that acts as a key regulator of lipid synthesis: mainly expressed by macrophages in lymphoid and inflamed tissues and regulates mechanisms in inflammatory responses, such as infection or atherosclerosis. Able to inhibit lipid droplet size in adipocytes. Following incorporation into mature adipocytes via CD36-mediated endocytosis, associates with cytosolic FASN, inhibiting fatty acid synthase activity and leading to lipolysis, the degradation of triacylglycerols into glycerol and free fatty acids (FFA). CD5L-induced lipolysis occurs with progression of obesity: participates in obesity-associated inflammation following recruitment of inflammatory macrophages into adipose tissues, a cause of insulin resistance and obesity-related metabolic disease. Regulation of intracellular lipids mediated by CD5L has a direct effect on transcription regulation mediated by nuclear receptors ROR-gamma (RORC).

1. Amézaga, N. et al. (2014) Journal of leukocyte biology 95, 509-20. PMID: 24295828

2. Sarrias, MR. et al. (2005) The Journal of biological chemistry 280, 35391-8. PMID: 16030018

3. Sanjurjo, L. et al. (2013) PloS one 8, e79670. PMID: 24223991

4. Martinez, VG. et al. (2014) Cellular & molecular immunology 11, 343-54. PMID: 24583716

5. Sanjurjo, L. et al. (2015) Autophagy 11, 487-502. PMID: 25713983

6. Arai, S. et al. (2016) Nature medicine 22, 183-93. PMID: 26726878

Nota

For research use only.

Imágenes

SDS-PAGE

SDS-PAGE for Anti-Human CD5L Antibody (SAA1515)

Referencias

Datasheet

Anti-Human CD5L Recombinant Antibody (SAA1515).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo