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| カタログ番号 | HT064013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | SAA1515 | ||||
| ターゲット | CD5 antigen-like, Apoptosis inhibitor expressed by macrophages, IgM-associated peptide, CT-2, hAIM, API6, SP-alpha, CD5L | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | O43866 | ||||
| RRID | Anti-Human CD5L Antibody (SAA1515) (abinScience Cat# HT064013, RRID:AB_3727276) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | CD5 antigen-like (CD5L) is a ~38 kDa protein. Secreted protein that acts as a key regulator of lipid synthesis: mainly expressed by macrophages in lymphoid and inflamed tissues and regulates mechanisms in inflammatory responses, such as infection or atherosclerosis. Able to inhibit lipid droplet size in adipocytes. Following incorporation into mature adipocytes via CD36-mediated endocytosis, associates with cytosolic FASN, inhibiting fatty acid synthase activity and leading to lipolysis, the degradation of triacylglycerols into glycerol and free fatty acids (FFA). CD5L-induced lipolysis occurs with progression of obesity: participates in obesity-associated inflammation following recruitment of inflammatory macrophages into adipose tissues, a cause of insulin resistance and obesity-related metabolic disease. Regulation of intracellular lipids mediated by CD5L has a direct effect on transcription regulation mediated by nuclear receptors ROR-gamma (RORC). 1. Amézaga, N. et al. (2014) Journal of leukocyte biology 95, 509-20. PMID: 24295828 2. Sarrias, MR. et al. (2005) The Journal of biological chemistry 280, 35391-8. PMID: 16030018 3. Sanjurjo, L. et al. (2013) PloS one 8, e79670. PMID: 24223991 4. Martinez, VG. et al. (2014) Cellular & molecular immunology 11, 343-54. PMID: 24583716 5. Sanjurjo, L. et al. (2015) Autophagy 11, 487-502. PMID: 25713983 6. Arai, S. et al. (2016) Nature medicine 22, 183-93. PMID: 26726878 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human CD5L Antibody (SAA1515)
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