Anti-Human CD85g/LILRA4 Recombinant Antibody (SAA0038) (HX894107)

Name: Anti-Human CD85g/LILRA4 Recombinant Antibody (SAA0038)
Brand: abinScience
SKU: HX894107
Price: 191 USD
Availability: InStock

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Aperçu

Numéro de catalogue	HX894107
Reactivité des espèces	Human
Applications	FCM
Espèce hôte	Human
Clonalité	Monoclonal
Isotype	IgG1, Lambda
ID de clone	SAA0038
Cible	CD85g, ILT7, Immunoglobulin-like transcript 7, LILRA4, Leukocyte immunoglobulin-like receptor subfamily A member 4, ILT-7, CD85 antigen-like family member G
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	P59901
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4 Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Contexte	Leukocyte immunoglobulin-like receptor subfamily A member 4 (CD85g/LILRA4) is a ~55 kDa protein. Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G. Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as a negative regulator of TLR7 and TLR9 signaling cascades. Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells. Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+). Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells. 1. Cao, W. et al. (2006) The Journal of experimental medicine 203, 1399-405. PMID: 16735691 2. Cao, W. et al. (2009) The Journal of experimental medicine 206, 1603-14. PMID: 19564354 3. Tavano, B. et al. (2014) PloS one 9, e89414. PMID: 24586760 4. Bego, MG. et al. (2015) PLoS pathogens 11, e1005024. PMID: 26172439
Note	For research use only.

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Flow Cytometry

Flow-cytometry using anti-human CD85g antibody.CD85g Transfected CHO cells were stained with an irrelevant antibody (Blue Histogram) or an anti-human CD85g antibody monoclonal antibody (Catalog # HX894107 ,Green Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a FITC conjugated goat anti-human antibody (Catalog # HF690414) and cells analysed on a NovoCyte Flow Cytometer.

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Anti-Human CD85g/LILRA4 Recombinant Antibody (SAA0038).pdf

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