Anti-Human LILRA4/CD85g/ILT7 Reference Antibody (Daxdilimab, RUO) (HX894016)

Name: Anti-Human LILRA4/CD85g/ILT7 Reference Antibody (Daxdilimab, RUO)
Brand: abinScience
SKU: HX894016
Price: 176 USD
Availability: InStock

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Overview

Catalog No.	HX894016
Description	Daxdilimab (HX894016) is a research-grade recombinant antibody targeting CD85. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG1-Lambda
Expression system	Mammalian cells
Clonality	Monoclonal
Target	CD85g, ILT7, Immunoglobulin-like transcript 7, LILRA4, Leukocyte immunoglobulin-like receptor subfamily A member 4, ILT-7, CD85 antigen-like family member G
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P59901
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	MEDI-7734, VIB-7734, 2245966-28-1
Background	Leukocyte immunoglobulin-like receptor subfamily A member 4 (CD85g/LILRA4) is a ~55 kDa protein. Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G. Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as a negative regulator of TLR7 and TLR9 signaling cascades. Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells. Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+). Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells. 1. Cao, W. et al. (2006) The Journal of experimental medicine 203, 1399-405. PMID: 16735691 2. Cao, W. et al. (2009) The Journal of experimental medicine 206, 1603-14. PMID: 19564354 3. Tavano, B. et al. (2014) PloS one 9, e89414. PMID: 24586760 4. Bego, MG. et al. (2015) PLoS pathogens 11, e1005024. PMID: 26172439
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE for Research Grade Daxdilimab

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Datasheet

Anti-Human LILRA4/CD85g/ILT7 Reference Antibody (Daxdilimab, RUO).pdf

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Anti-Human LILRA4/CD85g/ILT7 Reference Antibody (Daxdilimab, RUO) (HX894016)

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References

Datasheet

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