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| カタログ番号 | HD509014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human CDT1 Polyclonal Antibody (HD509014) is a rabbit polyclonal antibody detecting CDT1. Suitable for Human.
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CDT1 (Thr112-Ser386). | ||||||||
| ターゲット | CDT1, DNA replication factor Cdt1, DUP, Double parked homolog | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9H211 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 背景 | DNA replication factor Cdt1 is a ~60 kDa protein. Required for both DNA replication and mitosis. DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC). Required also for mitosis by promoting stable kinetochore-microtubule attachments. Potential oncogene. 1. Wohlschlegel, JA. et al. (2000) Science (New York, N.Y.) 290, 2309-12. PMID: 11125146 2. Sugimoto, N. et al. (2004) The Journal of biological chemistry 279, 19691-7. PMID: 14993212 3. Miotto, B. et al. (2011) Molecular cell 44, 62-71. PMID: 21856198 4. Varma, D. et al. (2012) Nature cell biology 14, 593-603. PMID: 22581055 5. Franz, A. et al. (2016) Nature communications 7, 10612. PMID: 26842564 6. Cook, JG. et al. (2004) The Journal of biological chemistry 279, 9625-33. PMID: 14672932 | ||||||||
| 注意事項 | For research use only |
Lane 1: HCT116 cell lysate
Lane 2: Jurkat cell lysate
Lane 3: K562 cell lysate
Lane 4: MCF-7 cell lysate
Lane 5: Hela cell lysate
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