中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HP795014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human CEP131 Polyclonal Antibody (HP795014) is a rabbit polyclonal antibody detecting CEP131 in ELISA, IHC, WB. Suitable for Human.
Highlights
|
||||||||
| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CEP131 (Arg750-Ala1020). | ||||||||
| ターゲット | AZI1, Pre-acrosome localization protein 1, Centrosomal protein of 131 kDa, KIAA1118, CEP131, 5-azacytidine-induced protein 1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9UPN4 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
||||||||
| 製品使用情報 |
| ||||||||
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Centrosomal protein of 131 kDa (CEP131) is a ~122 kDa protein. Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation. In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation. In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner. Also acts as a negative regulator of BBSome ciliary trafficking. Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail. 1. Graser, S. et al. (2007) The Journal of cell biology 179, 321-30. PMID: 17954613 2. Chavali, PL. et al. (2013) The EMBO journal 32, 3011-3. PMID: 24185901 3. Villumsen, BH. et al. (2013) The EMBO journal 32, 3029-40. PMID: 24121310 4. Tollenaere, MAX. et al. (2015) Nature communications 6, 10075. PMID: 26616734 5. Chamling, X. et al. (2014) PLoS genetics 10, e1004083. PMID: 24550735 6. Staples, CJ. et al. (2012) Journal of cell science 125, 4770-9. PMID: 22797915 7. Kodani, A. et al. (2015) eLife 4. PMID: 26297806 8. Denu, RA. et al. (2019) The Journal of biological chemistry 294, 6531-6549. PMID: 30804208 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-CEP131 polyclonal antibody at 1µg/ml on various samples.
Lane 1: Mouse testis lysate
Lane 2: Rat testis lysate
お問い合わせ
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
