

| Каталожный номер | HT321014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Human CEP290 Polyclonal Antibody (HT321014) is a rabbit polyclonal antibody detecting CEP290 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Реактивность видов | Human | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human CEP290 (Thr1289-Arg1416). | ||||||||
| Цель | Nephrocystin-6, KIAA0373, CEP290, Bardet-Biedl syndrome 14 protein, Tumor antigen se2-2, BBS14, NPHP6, Centrosomal protein of 290 kDa, Cancer/testis antigen 87, Cep290, CT87 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | O15078 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Centrosomal protein of 290 kDa (CEP290) is a ~290 kDa protein. Involved in early and late steps in cilia formation. Its association with CCP110 is required for inhibition of primary cilia formation by CCP110. May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1. Required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells; may play a role in ciliary transport processes. 1. Tsang, WY. et al. (2008) Developmental cell 15, 187-97. PMID: 18694559 2. Kobayashi, T. et al. (2014) The Journal of cell biology 204, 215-29. PMID: 24421332 3. Frank, V. et al. (2008) Human mutation 29, 45-52. PMID: 17705300 4. Barbelanne, M. et al. (2015) Human molecular genetics 24, 2185-200. PMID: 25552655 5. Sayer, JA. et al. (2006) Nature genetics 38, 674-81. PMID: 16682973 | ||||||||
| Примечание | For research use only. |
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