

| Numéro de catalogue | HD664014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-Human CEP63 Polyclonal Antibody (HD664014) is a rabbit polyclonal antibody detecting CEP63. Suitable for Human.
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| Reactivité des espèces | Human | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human CEP63 (Met1-Ile309). | ||||||||
| Cible | CEP63, Centrosomal protein of 63 kDa, Cep63 | ||||||||
| Niveau d'endotoxines | Please contact with the lab for this information. | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | Q96MT8 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Contexte | Centrosomal protein of 63 kDa (CEP63) is a ~81 kDa protein. Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Reported to be required for centrosomal recruitment of CEP152; however, this function has been questioned. Also recruits CDK1 to centrosomes. Plays a role in DNA damage response. 1. Löffler, H. et al. (2011) Cancer research 71, 2129-39. PMID: 21406398 2. Sir, JH. et al. (2011) Nature genetics 43, 1147-53. PMID: 21983783 3. Kodani, A. et al. (2015) eLife 4. PMID: 26297806 4. Kodani, A. et al. (2022) EMBO reports 23, e52211. PMID: 35793002 5. Ling, H. et al. (2022) Oncogene 41, 4433-4445. PMID: 35989368 | ||||||||
| Note | For research use only |
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