Anti-Human CFTR Monoclonal Antibody (1A509) (HY313025)

Name: Anti-Human CFTR Monoclonal Antibody (1A509)
Brand: abinScience
SKU: HY313025
Price: 106 USD
Availability: InStock

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Numéro de catalogue	HY313025
Description	Anti-Human CFTR Monoclonal Antibody (1A509) [1A509] (HY313025) is a mouse monoclonal antibody detecting CFTR in ELISA, IHC, WB. Suitable for Human. Highlights ●Recombinant — Superior batch-to-batch reproducibility with defined sequences. ●Multi-Application — Validated across multiple applications.
Reactivité des espèces	Human
Applications	ELISA, IHC, WB
Espèce hôte	Mouse
Clonalité	Monoclonal
Isotype	IgG
ID de clone	1A509
Immunogène	E. coli - derived recombinant human CFTR (Ile1203-Ser1426).
Cible	Cystic fibrosis transmembrane conductance regulator, CFTR, ATP-binding cassette sub-family C member 7, Channel conductance-controlling ATPase, EC:5.6.1.6, cAMP-dependent chloride channel, CFTR
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	P13569
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte	Cystic fibrosis transmembrane conductance regulator (CFTR) is a ~168 kDa protein. Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Possesses an intrinsic ATPase activity and utilizes ATP to gate its channel; the passive flow of anions through the channel is gated by cycles of ATP binding and hydrolysis by the ATP-binding domains. The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration. In vitro, mediates ATP-dependent glutathione flux. 1. Shah, VS. et al. (2016) Science (New York, N.Y.) 351, 503-7. PMID: 26823428 2. Ostedgaard, LS. et al. (2000) Proceedings of the National Academy of Sciences of the United States of America 97, 5657-62. PMID: 10792060 3. Ramjeesingh, M. et al. (2001) Biochemistry 40, 10700-6. PMID: 11524016 4. Cheng, J. et al. (2002) The Journal of biological chemistry 277, 3520-9. PMID: 11707463 5. Hallows, KR. et al. (2003) American journal of physiology. Cell physiology 284, C1297-308. PMID: 12519745 6. Silvis, MR. et al. (2003) The Journal of biological chemistry 278, 11554-60. PMID: 12529365 7. Chappe, V. et al. (2003) The Journal of physiology 548, 39-52. PMID: 12588899 8. Kogan, I. et al. (2003) The EMBO journal 22, 1981-9. PMID: 12727866 9. Shcheynikov, N. et al. (2004) The Journal of biological chemistry 279, 21857-65. PMID: 15010471 10. Mense, M. et al. (2006) The EMBO journal 25, 4728-39. PMID: 17036051
Note	For research use only.

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Anti-Human CFTR Monoclonal Antibody (1A509) (HY313025)

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