Anti-Human CFTR Polyclonal Antibody (HY313014)

Name: Anti-Human CFTR Polyclonal Antibody
Brand: abinScience
SKU: HY313014
Price: 168 USD
Availability: InStock

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SDS

Overview

Catalog No.

HY313014

Description

Anti-Human CFTR Polyclonal Antibody (HY313014) is a rabbit polyclonal antibody detecting CFTR in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CFTR (Ile1203-Ser1426).

Target

Cystic fibrosis transmembrane conductance regulator, CFTR, ATP-binding cassette sub-family C member 7, Channel conductance-controlling ATPase, 5.6.1.6, cAMP-dependent chloride channel, CFTR, ABCC7

Purification

Purified by antigen affinity column.

Accession

P13569

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Cystic fibrosis transmembrane conductance regulator (CFTR) is a ~168 kDa protein. Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Possesses an intrinsic ATPase activity and utilizes ATP to gate its channel; the passive flow of anions through the channel is gated by cycles of ATP binding and hydrolysis by the ATP-binding domains. The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration. In vitro, mediates ATP-dependent glutathione flux.

1. Shah, VS. et al. (2016) Science (New York, N.Y.) 351, 503-7. PMID: 26823428

2. Ostedgaard, LS. et al. (2000) Proceedings of the National Academy of Sciences of the United States of America 97, 5657-62. PMID: 10792060

3. Ramjeesingh, M. et al. (2001) Biochemistry 40, 10700-6. PMID: 11524016

4. Cheng, J. et al. (2002) The Journal of biological chemistry 277, 3520-9. PMID: 11707463

5. Hallows, KR. et al. (2003) American journal of physiology. Cell physiology 284, C1297-308. PMID: 12519745

6. Silvis, MR. et al. (2003) The Journal of biological chemistry 278, 11554-60. PMID: 12529365

7. Chappe, V. et al. (2003) The Journal of physiology 548, 39-52. PMID: 12588899

8. Kogan, I. et al. (2003) The EMBO journal 22, 1981-9. PMID: 12727866

9. Shcheynikov, N. et al. (2004) The Journal of biological chemistry 279, 21857-65. PMID: 15010471

10. Mense, M. et al. (2006) The EMBO journal 25, 4728-39. PMID: 17036051

Note

For research use only.

Images

References

Datasheet

Anti-Human CFTR Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human CFTR Polyclonal Antibody (HY313014)

Overview

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References

Datasheet

SDS

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