

| Numéro de catalogue | HD623014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-Human CMKLR2 Polyclonal Antibody (HD623014) is a rabbit polyclonal antibody detecting CMKLR2. Suitable for Human.
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| Reactivité des espèces | Human | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human CMKLR2 (Glu2-Ser41&Ser308-Gln355). | ||||||||
| Cible | CMKLR2, Chemerin chemokine-like receptor 2, Chemerin-like receptor 2, Chemokine-like receptor 2, G-protein coupled receptor 1, GPR1 | ||||||||
| Niveau d'endotoxines | Please contact with the lab for this information. | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | P46091 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Contexte | Chemerin-like receptor 2 (CMKLR2) is a ~41 kDa protein. Receptor for chemoattractant adipokine chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation and energy homesotasis. Signals mainly via beta-arrestin pathway. Binding of RARRES2 activates weakly G proteins, calcium mobilization and MAPK1/MAPK3 (ERK1/2) phosphorylation too. Also acts as a receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway. 1. Barnea, G. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 64-9. PMID: 18165312 2. De Henau, O. et al. (2016) PloS one 11, e0164179. PMID: 27716822 | ||||||||
| Note | For research use only |
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