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| カタログ番号 | HW810013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | SAA1641 | ||||
| ターゲット | TSP5, Thrombospondin-5, COMP, Cartilage oligomeric matrix protein | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | P49747 | ||||
| RRID | Anti-Human COMP Antibody (SAA1641) (abinScience Cat# HW810013, RRID:AB_3727402) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Cartilage oligomeric matrix protein (COMP) is a ~82 kDa protein. Plays a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). 1. Chen, FH. et al. (2005) The Journal of biological chemistry 280, 32655-61. PMID: 16051604 2. Koelling, S. et al. (2006) Arthritis research & therapy 8, R56. PMID: 16542502 3. Gagarina, V. et al. (2008) The Journal of biological chemistry 283, 648-659. PMID: 17993464 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human COMP Antibody (SAA1641)
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