Anti-COMP Polyclonal Antibody (HW810014)

Name: Anti-COMP Polyclonal Antibody
Brand: abinScience
SKU: HW810014
Price: 168 USD
Availability: InStock

Datasheet Share product Copy info

Price(USD):

Spec:

50ug
100ug

Number:

Get quote

Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HW810014

Description

Anti-COMP Polyclonal Antibody (HW810014) is a rabbit polyclonal antibody detecting COMP in ELISA, IHC, WB. Suitable for Bovine, Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human COMP (Ser123-His240).

Target

TSP5, Thrombospondin-5, COMP, Cartilage oligomeric matrix protein

Purification

Purified by antigen affinity column.

Accession

P49747

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Cartilage oligomeric matrix protein (COMP) is a ~82 kDa protein. Plays a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP).

1. Chen, FH. et al. (2005) The Journal of biological chemistry 280, 32655-61. PMID: 16051604

2. Koelling, S. et al. (2006) Arthritis research & therapy 8, R56. PMID: 16542502

3. Gagarina, V. et al. (2008) The Journal of biological chemistry 283, 648-659. PMID: 17993464

Note

For research use only.

Images

References

Datasheet

Anti-COMP Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-COMP Polyclonal Antibody (HW810014)

Overview

Images

References

Datasheet

SDS

Quick access

Contact Us