Anti-Human CRBN Polyclonal Antibody (HP395014)

Name: Anti-Human CRBN Polyclonal Antibody
Brand: abinScience
SKU: HP395014
Price: 168 USD
Availability: InStock

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Especificación:

50ug
100ug

Número:

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Número de catálogo

HP395014

Descripción

Anti-Human CRBN Polyclonal Antibody (HP395014) is a rabbit polyclonal antibody detecting CRBN in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactividad de especies

Human, Mouse, Rat

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human CRBN (Met1-Leu442).

Objetivo

Protein cereblon, CRBN, AD-006

Purificación

Purified by antigen affinity column.

Número de acceso

Q96SW2

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Protein cereblon (CRBN) is a ~50 kDa protein. Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2, ILF2 or GLUL. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. Maintains presynaptic glutamate release and consequently cognitive functions, such as memory and learning, by negatively regulating large-conductance calcium-activated potassium (BK) channels in excitatory neurons. Likely to function by regulating the assembly and neuronal surface expression of BK channels via its interaction with KCNT1. May also be involved in regulating anxiety-like behaviors via a BK channel-independent mechanism.

1. Nguyen, TV. et al. (2016) Molecular cell 61, 809-20. PMID: 26990986

2. Lian, Q. et al. (2020) The protein journal 39, 411-421. PMID: 33009960

3. Ito, T. et al. (2010) Science (New York, N.Y.) 327, 1345-50. PMID: 20223979

4. Gandhi, AK. et al. (2014) British journal of haematology 164, 811-21. PMID: 24328678

5. Fischer, ES. et al. (2014) Nature 512, 49-53. PMID: 25043012

6. Chamberlain, PP. et al. (2014) Nature structural & molecular biology 21, 803-9. PMID: 25108355

7. Higgins, JJ. et al. (2008) Neurogenetics 9, 219-23. PMID: 18414909

8. Choi, TY. et al. (2018) The Journal of neuroscience : the official journal of the Society for Neuroscience 38, 3571-3583. PMID: 29530986

9. Kim, MJ. et al. (2019) Frontiers in immunology 10, 2203. PMID: 31620128

Nota

For research use only.

Imágenes

Referencias

Datasheet

Anti-Human CRBN Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo

Anti-Human CRBN Polyclonal Antibody (HP395014)

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Referencias

Datasheet

SDS