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| カタログ番号 | HP395014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human CRBN Polyclonal Antibody (HP395014) is a rabbit polyclonal antibody detecting CRBN in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CRBN (Met1-Leu442). | ||||||||
| ターゲット | Protein cereblon, CRBN, AD-006 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q96SW2 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Protein cereblon (CRBN) is a ~50 kDa protein. Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2, ILF2 or GLUL. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. Maintains presynaptic glutamate release and consequently cognitive functions, such as memory and learning, by negatively regulating large-conductance calcium-activated potassium (BK) channels in excitatory neurons. Likely to function by regulating the assembly and neuronal surface expression of BK channels via its interaction with KCNT1. May also be involved in regulating anxiety-like behaviors via a BK channel-independent mechanism. 1. Nguyen, TV. et al. (2016) Molecular cell 61, 809-20. PMID: 26990986 2. Lian, Q. et al. (2020) The protein journal 39, 411-421. PMID: 33009960 3. Ito, T. et al. (2010) Science (New York, N.Y.) 327, 1345-50. PMID: 20223979 4. Gandhi, AK. et al. (2014) British journal of haematology 164, 811-21. PMID: 24328678 5. Fischer, ES. et al. (2014) Nature 512, 49-53. PMID: 25043012 6. Chamberlain, PP. et al. (2014) Nature structural & molecular biology 21, 803-9. PMID: 25108355 7. Higgins, JJ. et al. (2008) Neurogenetics 9, 219-23. PMID: 18414909 8. Choi, TY. et al. (2018) The Journal of neuroscience : the official journal of the Society for Neuroscience 38, 3571-3583. PMID: 29530986 9. Kim, MJ. et al. (2019) Frontiers in immunology 10, 2203. PMID: 31620128 | ||||||||
| 注意事項 | For research use only. |
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