Anti-Human CRBN Polyclonal Antibody (HP395014)

Name: Anti-Human CRBN Polyclonal Antibody
Brand: abinScience
SKU: HP395014
Price: 168 USD
Availability: InStock

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Каталожный номер

HP395014

Описание

Anti-Human CRBN Polyclonal Antibody (HP395014) is a rabbit polyclonal antibody detecting CRBN in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Реактивность видов

Human, Mouse, Rat

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human CRBN (Met1-Leu442).

Цель

Protein cereblon, CRBN, AD-006

Очистка

Purified by antigen affinity column.

Номер доступа

Q96SW2

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Protein cereblon (CRBN) is a ~50 kDa protein. Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2, ILF2 or GLUL. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. Maintains presynaptic glutamate release and consequently cognitive functions, such as memory and learning, by negatively regulating large-conductance calcium-activated potassium (BK) channels in excitatory neurons. Likely to function by regulating the assembly and neuronal surface expression of BK channels via its interaction with KCNT1. May also be involved in regulating anxiety-like behaviors via a BK channel-independent mechanism.

1. Nguyen, TV. et al. (2016) Molecular cell 61, 809-20. PMID: 26990986

2. Lian, Q. et al. (2020) The protein journal 39, 411-421. PMID: 33009960

3. Ito, T. et al. (2010) Science (New York, N.Y.) 327, 1345-50. PMID: 20223979

4. Gandhi, AK. et al. (2014) British journal of haematology 164, 811-21. PMID: 24328678

5. Fischer, ES. et al. (2014) Nature 512, 49-53. PMID: 25043012

6. Chamberlain, PP. et al. (2014) Nature structural & molecular biology 21, 803-9. PMID: 25108355

7. Higgins, JJ. et al. (2008) Neurogenetics 9, 219-23. PMID: 18414909

8. Choi, TY. et al. (2018) The Journal of neuroscience : the official journal of the Society for Neuroscience 38, 3571-3583. PMID: 29530986

9. Kim, MJ. et al. (2019) Frontiers in immunology 10, 2203. PMID: 31620128

Примечание

For research use only.

Изображения

Ссылки

Даташит

Anti-Human CRBN Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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Anti-Human CRBN Polyclonal Antibody (HP395014)

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