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Anti-Human CTNS Polyclonal Antibody (HF632014)

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Vista general
Número de catálogoHF632014
Descripción
Anti-Human CTNS Polyclonal Antibody (HF632014) is a rabbit polyclonal antibody detecting CTNS in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactividad de especiesHuman
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human CTNS (Ser22-Ser120).
Objetivo CTNS, Cystinosin
Purificación Purified by antigen affinity column.
Número de acceso O60931
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Cystinosin (CTNS) is a ~41 kDa protein. Cystine/H(+) symporter that mediates export of cystine, the oxidized dimer of cysteine, from lysosomes. Plays an important role in melanin synthesis by catalyzing cystine export from melanosomes, possibly by inhibiting pheomelanin synthesis. In addition to cystine export, also acts as a positive regulator of mTORC1 signaling in kidney proximal tubular cells, via interactions with components of the v-ATPase and Ragulator complexes. Also involved in small GTPase-regulated vesicle trafficking and lysosomal localization of LAMP2A, independently of cystine transporter activity.

1. Kalatzis, V. et al. (2001) The EMBO journal 20, 5940-9. PMID: 11689434
2. Kalatzis, V. et al. (2004) Human molecular genetics 13, 1361-71. PMID: 15128704
3. Taranta, A. et al. (2008) American journal of physiology. Renal physiology 294, F1101-8. PMID: 18337546
4. Ruivo, R. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, E210-7. PMID: 22232659
5. Deshpande, AA. et al. (2018) Scientific reports 8, 3442. PMID: 29467429
6. Adelmann, CH. et al. (2020) Nature 588, 699-704. PMID: 33208952
7. Guo, X. et al. (2022) Cell 185, 3739-3752.e18. PMID: 36113465
8. Chiaverini, C. et al. (2012) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 26, 3779-89. PMID: 22649030
Nota For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Human CTNS Polyclonal Antibody

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