Human CTNS Recombinant Protein (N-GST & C-His) (HF632022)

Name: Human CTNS Recombinant Protein (N-GST & C-His)
Brand: abinScience
SKU: HF632022
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HF632022
Description	Recombinant Human CTNS Protein, N-GST & C-His (HF632022) expressed in E. coli, spanning Ser22-Ser120. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	O60931
Protein length	Ser22-Ser120
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	38.92 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	CTNS, Cystinosin
Background	Cystinosin is a ~41 kDa protein. Cystine/H(+) symporter that mediates export of cystine, the oxidized dimer of cysteine, from lysosomes. Plays an important role in melanin synthesis by catalyzing cystine export from melanosomes, possibly by inhibiting pheomelanin synthesis. In addition to cystine export, also acts as a positive regulator of mTORC1 signaling in kidney proximal tubular cells, via interactions with components of the v-ATPase and Ragulator complexes. Also involved in small GTPase-regulated vesicle trafficking and lysosomal localization of LAMP2A, independently of cystine transporter activity. 1. Kalatzis, V. et al. (2001) The EMBO journal 20, 5940-9. PMID: 11689434 2. Kalatzis, V. et al. (2004) Human molecular genetics 13, 1361-71. PMID: 15128704 3. Taranta, A. et al. (2008) American journal of physiology. Renal physiology 294, F1101-8. PMID: 18337546 4. Ruivo, R. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, E210-7. PMID: 22232659 5. Deshpande, AA. et al. (2018) Scientific reports 8, 3442. PMID: 29467429 6. Adelmann, CH. et al. (2020) Nature 588, 699-704. PMID: 33208952 7. Guo, X. et al. (2022) Cell 185, 3739-3752.e18. PMID: 36113465 8. Chiaverini, C. et al. (2012) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 26, 3779-89. PMID: 22649030
Note	For research use only

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Datasheet

Human CTNS Recombinant Protein (N-GST & C-His).pdf

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Human CTNS Recombinant Protein (N-GST & C-His) (HF632022)

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