Anti-Human CTNS Polyclonal Antibody (HF632014)

Name: Anti-Human CTNS Polyclonal Antibody
Brand: abinScience
SKU: HF632014
Price: 168 USD
Availability: InStock

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Datasheet
SDS

Overview

Catalog No.

HF632014

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CTNS (Ser22-Ser120).

Target

CTNS, Cystinosin

Purification

Purified by antigen affinity column.

Accession

O60931

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Cystinosin (CTNS) is a ~41 kDa protein. Cystine/H(+) symporter that mediates export of cystine, the oxidized dimer of cysteine, from lysosomes. Plays an important role in melanin synthesis by catalyzing cystine export from melanosomes, possibly by inhibiting pheomelanin synthesis. In addition to cystine export, also acts as a positive regulator of mTORC1 signaling in kidney proximal tubular cells, via interactions with components of the v-ATPase and Ragulator complexes. Also involved in small GTPase-regulated vesicle trafficking and lysosomal localization of LAMP2A, independently of cystine transporter activity.

1. Kalatzis, V. et al. (2001) The EMBO journal 20, 5940-9. PMID: 11689434

2. Kalatzis, V. et al. (2004) Human molecular genetics 13, 1361-71. PMID: 15128704

3. Taranta, A. et al. (2008) American journal of physiology. Renal physiology 294, F1101-8. PMID: 18337546

4. Ruivo, R. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, E210-7. PMID: 22232659

5. Deshpande, AA. et al. (2018) Scientific reports 8, 3442. PMID: 29467429

6. Adelmann, CH. et al. (2020) Nature 588, 699-704. PMID: 33208952

7. Guo, X. et al. (2022) Cell 185, 3739-3752.e18. PMID: 36113465

8. Chiaverini, C. et al. (2012) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 26, 3779-89. PMID: 22649030

Note

For research use only.

Images

References

Datasheet

Anti-Human CTNS Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-Human CTNS Polyclonal Antibody (HF632014)

Overview

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References

Datasheet

SDS

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