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Anti-Human CUL4A Polyclonal Antibody (HC663024)

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Vista general
Número de catálogoHC663024
Descripción
Anti-Human CUL4A Polyclonal Antibody (HC663024) is a rabbit polyclonal antibody detecting CUL4A. Suitable for Human and Mouse.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Reactividad de especiesHuman, Mouse
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human CUL4A (Gln570-Ala759).
Objetivo CUL-4A, CUL4A, Cullin-4A
Nivel de endotoxinas Please contact with the lab for this information.
Purificación Purified by antigen affinity column.
Número de acceso Q13619
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Fondo

Cullin-4A (CUL4A) is a ~87 kDa protein. Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN.

1. Higa, LA. et al. (2003) Nature cell biology 5, 1008-15. PMID: 14578910
2. Wertz, IE. et al. (2004) Science (New York, N.Y.) 303, 1371-4. PMID: 14739464
3. Hu, J. et al. (2004) Nature cell biology 6, 1003-9. PMID: 15448697
4. Nag, A. et al. (2004) Cancer research 64, 8152-5. PMID: 15548678
5. Matsuda, N. et al. (2005) DNA repair 4, 537-45. PMID: 15811626
6. Wang, H. et al. (2006) Molecular cell 22, 383-94. PMID: 16678110
7. Higa, LA. et al. (2006) Nature cell biology 8, 1277-83. PMID: 17041588
8. Han, J. et al. (2013) Cell 155, 817-29. PMID: 24209620
9. Chen, SH. et al. (2018) The EMBO journal 37. PMID: 30166453
10. Maiani, E. et al. (2021) Nature 592, 799-803. PMID: 33854232
Nota For research use only
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Formula
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Formula
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Working Solution
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