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Anti-Human DHX16 Polyclonal Antibody (HT408014)

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Aperçu
Numéro de catalogueHT408014
Description
Anti-Human DHX16 Polyclonal Antibody (HT408014) is a rabbit polyclonal antibody detecting DHX16 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactivité des espècesHuman
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Human DHX16 (Glu364-Glu746).
Cible Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16, 3.6.4.13, ATP-dependent RNA helicase #3, DEAH-box protein 16, DHX16, DBP2, DDX16, KIAA0577, PRP2
Purification Purified by antigen affinity column.
Numéro d'accès O60231
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte

Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 is a ~119 kDa protein. Required for pre-mRNA splicing as a component of the spliceosome. Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Also plays a role in innate antiviral response by acting as a pattern recognition receptor sensing splicing signals in viral RNA. Mechanistically, TRIM6 promotes the interaction between unanchored 'Lys-48'-polyubiquitin chains and DHX16, leading to DHX16 interaction with RIGI and ssRNA to amplify RIGI-dependent innate antiviral immune responses.

1. Gencheva, M. et al. (2010) The Biochemical journal 429, 25-32. PMID: 20423332
2. Gencheva, M. et al. (2010) The Journal of biological chemistry 285, 35624-32. PMID: 20841358
3. Zang, S. et al. (2014) Bioscience reports 34, e00163. PMID: 25296192
4. Zhang, X. et al. (2018) Cell research 28, 307-322. PMID: 29360106
5. Hage, A. et al. (2022) Cell reports 38, 110434. PMID: 35263596
Note For research use only.
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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Working Solution
C₂ (Working Conc.)
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Anti-Human DHX16 Polyclonal Antibody

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