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| カタログ番号 | HT408014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human DHX16 Polyclonal Antibody (HT408014) is a rabbit polyclonal antibody detecting DHX16 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human DHX16 (Glu364-Glu746). | ||||||||
| ターゲット | Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16, 3.6.4.13, ATP-dependent RNA helicase #3, DEAH-box protein 16, DHX16, DBP2, DDX16, KIAA0577, PRP2 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O60231 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 is a ~119 kDa protein. Required for pre-mRNA splicing as a component of the spliceosome. Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Also plays a role in innate antiviral response by acting as a pattern recognition receptor sensing splicing signals in viral RNA. Mechanistically, TRIM6 promotes the interaction between unanchored 'Lys-48'-polyubiquitin chains and DHX16, leading to DHX16 interaction with RIGI and ssRNA to amplify RIGI-dependent innate antiviral immune responses. 1. Gencheva, M. et al. (2010) The Biochemical journal 429, 25-32. PMID: 20423332 2. Gencheva, M. et al. (2010) The Journal of biological chemistry 285, 35624-32. PMID: 20841358 3. Zang, S. et al. (2014) Bioscience reports 34, e00163. PMID: 25296192 4. Zhang, X. et al. (2018) Cell research 28, 307-322. PMID: 29360106 5. Hage, A. et al. (2022) Cell reports 38, 110434. PMID: 35263596 | ||||||||
| 注意事項 | For research use only. |
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