Anti-Human DSG2 Recombinant Antibody (3D3), APC (HC461137)

Name: Anti-Human DSG2 Recombinant Antibody (3D3), APC
Brand: abinScience
SKU: HC461137
Price: 256 USD
Availability: InStock

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Número de catálogo	HC461137
Reactividad de especies	Human
Aplicaciones	ELISA, FCM, WB
Especie huésped	Mouse
Clonalidad	Monoclonal
Isotipo	IgG2a, kappa
ID de clon	3D3
Conjugación	APC
Objetivo	CDHF5, HDGC, Desmoglein-2, DSG2, Cadherin family member 5
Nivel de endotoxinas	Please contact with the lab for this information.
Productos asociados	Mouse IgG2a, kappa Recombinant Isotype Control Antibody (MOPC-173), APC
Número de acceso	Q14126
Forma	Liquid
Buffer de almacenamiento	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Store at 4°C for 12 months. Protect from light. Do not freeze.
Fondo	Desmoglein-2 (DSG2) is a ~122 kDa protein. A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development. Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes. Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells. 1. Cirillo, N. et al. (2008) Journal of cellular biochemistry 103, 598-606. PMID: 17559062 2. Xu, T. et al. (2024) Kidney international 105, 1035-1048. PMID: 38395410 3. Park, J. et al. (2018) Stem cell reports 11, 115-127. PMID: 29910125 4. Ebert, LM. et al. (2016) Angiogenesis 19, 463-86. PMID: 27338829 5. Overmiller, AM. et al. (2016) Oncotarget 7, 37536-37555. PMID: 26918609
Nota	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Human DSG2 Recombinant Antibody (3D3), APC.pdf

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