Anti-Human DSG2 Recombinant Antibody (3D3), PE (HC461127)

Name: Anti-Human DSG2 Recombinant Antibody (3D3), PE
Brand: abinScience
SKU: HC461127
Price: 256 USD
Availability: InStock

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Overview

Catalog No.	HC461127
Species reactivity	Human
Applications	ELISA, FCM, WB
Host species	Mouse
Isotype	IgG2a, kappa
Clone ID	3D3
Conjugation	PE
Clonality	Monoclonal
Target	CDHF5, HDGC, Desmoglein-2, DSG2, Cadherin family member 5
Endotoxin level	Please contact with the lab for this information.
Associated products	Mouse IgG2a, kappa Recombinant Isotype Control Antibody (MOPC-173), PE
Accession	Q14126
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Background	Desmoglein-2 (DSG2) is a ~122 kDa protein. A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development. Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes. Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells. 1. Cirillo, N. et al. (2008) Journal of cellular biochemistry 103, 598-606. PMID: 17559062 2. Xu, T. et al. (2024) Kidney international 105, 1035-1048. PMID: 38395410 3. Park, J. et al. (2018) Stem cell reports 11, 115-127. PMID: 29910125 4. Ebert, LM. et al. (2016) Angiogenesis 19, 463-86. PMID: 27338829 5. Overmiller, AM. et al. (2016) Oncotarget 7, 37536-37555. PMID: 26918609
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Human DSG2 Recombinant Antibody (3D3), PE.pdf

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Anti-Human DSG2 Recombinant Antibody (3D3), PE (HC461127)

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