Anti-Human DSG2 Recombinant Antibody (3D3) (HC461107)

Name: Anti-Human DSG2 Recombinant Antibody (3D3)
Brand: abinScience
SKU: HC461107
Price: 196 USD
Availability: InStock

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Número de catálogo	HC461107
Reactividad de especies	Human
Aplicaciones	Blocking, ELISA, FCM, WB
Especie huésped	Mouse
Clonalidad	Monoclonal
Isotipo	IgG2a, kappa
ID de clon	3D3
Objetivo	CDHF5, HDGC, Desmoglein-2, DSG2, Cadherin family member 5
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>95% as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	Q14126
Forma	Liquid
Buffer de almacenamiento	0.01M PBS, pH 7.4, 0.09% Sodium azide. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Fondo	Desmoglein-2 (DSG2) is a ~122 kDa protein. A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development. Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes. Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells. 1. Cirillo, N. et al. (2008) Journal of cellular biochemistry 103, 598-606. PMID: 17559062 2. Xu, T. et al. (2024) Kidney international 105, 1035-1048. PMID: 38395410 3. Park, J. et al. (2018) Stem cell reports 11, 115-127. PMID: 29910125 4. Ebert, LM. et al. (2016) Angiogenesis 19, 463-86. PMID: 27338829 5. Overmiller, AM. et al. (2016) Oncotarget 7, 37536-37555. PMID: 26918609
Nota	For research use only.

Imágenes

SDS-PAGE

SDS-PAGE for Anti-Human DSG2 Antibody (3D3)

Referencias

Datasheet

Anti-Human DSG2 Recombinant Antibody (3D3).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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C₁ × V₁ = C₂ × V₂

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C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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