Anti-Human DSG2 Recombinant Antibody (3D3) (HC461107)

Name: Anti-Human DSG2 Recombinant Antibody (3D3)
Brand: abinScience
SKU: HC461107
Price: 196 USD
Availability: InStock

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Каталожный номер	HC461107
Реактивность видов	Human
Применения	Blocking, ELISA, FCM, WB
Хозяинский вид	Mouse
Клоональность	Monoclonal
Изотип	IgG2a, kappa
ID клона	3D3
Цель	CDHF5, HDGC, Desmoglein-2, DSG2, Cadherin family member 5
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>95% as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	Q14126
Форма	Liquid
Буфер хранения	0.01M PBS, pH 7.4, 0.09% Sodium azide. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Фон	Desmoglein-2 (DSG2) is a ~122 kDa protein. A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development. Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes. Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells. 1. Cirillo, N. et al. (2008) Journal of cellular biochemistry 103, 598-606. PMID: 17559062 2. Xu, T. et al. (2024) Kidney international 105, 1035-1048. PMID: 38395410 3. Park, J. et al. (2018) Stem cell reports 11, 115-127. PMID: 29910125 4. Ebert, LM. et al. (2016) Angiogenesis 19, 463-86. PMID: 27338829 5. Overmiller, AM. et al. (2016) Oncotarget 7, 37536-37555. PMID: 26918609
Примечание	For research use only.

Изображения

SDS-PAGE

SDS-PAGE for Anti-Human DSG2 Antibody (3D3)

Ссылки

Даташит

Anti-Human DSG2 Recombinant Antibody (3D3).pdf

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