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Anti-Human DZIP1 Polyclonal Antibody (HP137014)

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Vista general
Número de catálogoHP137014
Descripción
Anti-Human DZIP1 Polyclonal Antibody (HP137014) is a rabbit polyclonal antibody detecting DZIP1 in ELISA, IHC, WB. Suitable for Human, Mouse.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Reactividad de especiesHuman, Mouse
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human DZIP1 (Ser66-Asp114).
Objetivo DAZ-interacting protein 1/2, DZIP1, Zinc finger protein DZIP1, DZIP, KIAA0996, DZIP2
Purificación Purified by antigen affinity column.
Número de acceso Q86YF9
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Cilium assembly protein DZIP1 is a ~98 kDa protein. Molecular adapter that recruits protein complexes required for cilium assembly and function to the cilium basal body. At the exit of mitosis, localizes to the basal body and ciliary base of the forming primary cilium where it recruits and activates RAB8A to direct vesicle-mediated transport of proteins to the cilium. Also recruits the BBSome, a complex involved in cilium biogenesis, by bridging it to PCM1 at the centriolar satellites of the cilium. It is also required for the recruitment to the cilium basal body of the intraflagellar transport (IFT) machinery as well as the ciliary appendage proteins CEP164 and NINEIN. Functions as a regulator of Hedgehog signaling both through its role in cilium assembly but also probably through its ability to retain GLI3 within the cytoplasm.

1. Glazer, AM. et al. (2010) Developmental biology 337, 148-56. PMID: 19852954
2. Wang, C. et al. (2013) The Journal of biological chemistry 288, 29518-29. PMID: 23955340
3. Zhang, B. et al. (2017) The Journal of biological chemistry 292, 1351-1360. PMID: 27979967
4. Lv, M. et al. (2020) Journal of medical genetics 57, 445-453. PMID: 32051257
5. Toomer, KA. et al. (2019) Science translational medicine 11. PMID: 31118289
Nota For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Human DZIP1 Polyclonal Antibody

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