Human DZIP1 Recombinant Protein (N-His) (HP137022)

Name: Human DZIP1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HP137022
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HP137022
Description	Recombinant Human DZIP1 Protein, N-His (HP137022) expressed in E. coli, spanning Met1-Asp114. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q86YF9
Protein length	Met1-Asp114
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	14.35 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	Cilium assembly protein DZIP1, DAZ-interacting protein 1/2, DAZ-interacting zinc finger protein 1, DZIP, DZIP1, DZIP2, KIAA0996
Background	Cilium assembly protein DZIP1 is a ~98 kDa protein. Molecular adapter that recruits protein complexes required for cilium assembly and function to the cilium basal body. At the exit of mitosis, localizes to the basal body and ciliary base of the forming primary cilium where it recruits and activates RAB8A to direct vesicle-mediated transport of proteins to the cilium. Also recruits the BBSome, a complex involved in cilium biogenesis, by bridging it to PCM1 at the centriolar satellites of the cilium. It is also required for the recruitment to the cilium basal body of the intraflagellar transport (IFT) machinery as well as the ciliary appendage proteins CEP164 and NINEIN. Functions as a regulator of Hedgehog signaling both through its role in cilium assembly but also probably through its ability to retain GLI3 within the cytoplasm. 1. Glazer, AM. et al. (2010) Developmental biology 337, 148-56. PMID: 19852954 2. Wang, C. et al. (2013) The Journal of biological chemistry 288, 29518-29. PMID: 23955340 3. Zhang, B. et al. (2017) The Journal of biological chemistry 292, 1351-1360. PMID: 27979967 4. Lv, M. et al. (2020) Journal of medical genetics 57, 445-453. PMID: 32051257 5. Toomer, KA. et al. (2019) Science translational medicine 11. PMID: 31118289
Note	For research use only

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Datasheet

Human DZIP1 Recombinant Protein (N-His).pdf

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Human DZIP1 Recombinant Protein (N-His) (HP137022)

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