Anti-Human DZIP1 Polyclonal Antibody (HP137014)

Name: Anti-Human DZIP1 Polyclonal Antibody
Brand: abinScience
SKU: HP137014
Price: 168 USD
Availability: InStock

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Overview

Catalog No.

HP137014

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human DZIP1 (Ser66-Asp114).

Target

DAZ-interacting protein 1/2, DZIP1, Zinc finger protein DZIP1, DZIP, KIAA0996, DZIP2

Purification

Purified by antigen affinity column.

Accession

Q86YF9

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Cilium assembly protein DZIP1 is a ~98 kDa protein. Molecular adapter that recruits protein complexes required for cilium assembly and function to the cilium basal body. At the exit of mitosis, localizes to the basal body and ciliary base of the forming primary cilium where it recruits and activates RAB8A to direct vesicle-mediated transport of proteins to the cilium. Also recruits the BBSome, a complex involved in cilium biogenesis, by bridging it to PCM1 at the centriolar satellites of the cilium. It is also required for the recruitment to the cilium basal body of the intraflagellar transport (IFT) machinery as well as the ciliary appendage proteins CEP164 and NINEIN. Functions as a regulator of Hedgehog signaling both through its role in cilium assembly but also probably through its ability to retain GLI3 within the cytoplasm.

1. Glazer, AM. et al. (2010) Developmental biology 337, 148-56. PMID: 19852954

2. Wang, C. et al. (2013) The Journal of biological chemistry 288, 29518-29. PMID: 23955340

3. Zhang, B. et al. (2017) The Journal of biological chemistry 292, 1351-1360. PMID: 27979967

4. Lv, M. et al. (2020) Journal of medical genetics 57, 445-453. PMID: 32051257

5. Toomer, KA. et al. (2019) Science translational medicine 11. PMID: 31118289

Note

For research use only.

Images

References

Datasheet

Anti-Human DZIP1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-Human DZIP1 Polyclonal Antibody (HP137014)

Overview

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References

Datasheet

SDS

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