

| Numéro de catalogue | HP137014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-Human DZIP1 Polyclonal Antibody (HP137014) is a rabbit polyclonal antibody detecting DZIP1 in ELISA, IHC, WB. Suitable for Human, Mouse.
Highlights
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| Reactivité des espèces | Human, Mouse | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human DZIP1 (Ser66-Asp114). | ||||||||
| Cible | DAZ-interacting protein 1/2, DZIP1, Zinc finger protein DZIP1, DZIP, KIAA0996, DZIP2 | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | Q86YF9 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | Cilium assembly protein DZIP1 is a ~98 kDa protein. Molecular adapter that recruits protein complexes required for cilium assembly and function to the cilium basal body. At the exit of mitosis, localizes to the basal body and ciliary base of the forming primary cilium where it recruits and activates RAB8A to direct vesicle-mediated transport of proteins to the cilium. Also recruits the BBSome, a complex involved in cilium biogenesis, by bridging it to PCM1 at the centriolar satellites of the cilium. It is also required for the recruitment to the cilium basal body of the intraflagellar transport (IFT) machinery as well as the ciliary appendage proteins CEP164 and NINEIN. Functions as a regulator of Hedgehog signaling both through its role in cilium assembly but also probably through its ability to retain GLI3 within the cytoplasm. 1. Glazer, AM. et al. (2010) Developmental biology 337, 148-56. PMID: 19852954 2. Wang, C. et al. (2013) The Journal of biological chemistry 288, 29518-29. PMID: 23955340 3. Zhang, B. et al. (2017) The Journal of biological chemistry 292, 1351-1360. PMID: 27979967 4. Lv, M. et al. (2020) Journal of medical genetics 57, 445-453. PMID: 32051257 5. Toomer, KA. et al. (2019) Science translational medicine 11. PMID: 31118289 | ||||||||
| Note | For research use only. |
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